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KMID : 1234420100380040405
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 4 p.405 ~ p.413
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Synergistic Antibacterial Activity of Fig (Ficus carica) Leaves Extract Against Clinical Isolates of Methicillin-resistant Staphylococcus
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Lee Young-Soo
Cha Jeong-Dan
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Abstract
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Fig (Ficus carica L.) belongs to the mulberry tree (Moraceae) which is one of the oldest fruits in the world. It has been used as a digestion promoter and a cure for ulcerative inflammation and eruption in Korea. The present study investigated the antimicrobial activity of methanol (MeOH) extract of fig leaves against methicillin- resistant Staphylococcus aureus (MRSA) isolated in clinic. The MeOH extract (MICs, 2.5 to 20 mg/mL; MBCs, 5 to 20 mg/mL) was demonstrated as antibacterial activity in isolates MRSA 1-20. The administration of the MeOH extract in combination with oxacillin or ampicillin induced a reduction of ≥4-8-fold in all tested bacteria, which was considered to be synergistic based on a FICI of ≤ 0.375-0.5. Furthermore, time-kill study was found that a combination of MeOH extract with oxacillin or ampicillin produced a more rapid decrease in the concentration of bacteria CFU/mL than MeOH extract alone. The results suggest that fig leaves could be employed as a natural antibacterial agent in MRSA infection care products.
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KEYWORD
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Ficus carica (fig), methicillin-resistant Staphylococcus aureus, antibacterial activity, minimum inhibitory concentration, minimum bactericidal concentration, synergistic effect
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